Clinical resources

Nano-Pulse Stimulation™ (NPS™) technology

Pulse Biosciences supports clinical research dedicated to the development of scientific evidence supporting improvements in the use of NPS technology. Scientific publications, presentations, abstracts and posters are provided below for educational purposes to the use of NPS technology in the clinical setting.

The CellFX® System uses Nano-Pulse Stimulation (NPS) technology and has been CE mark approved with indication of use in dermatologic procedures requiring ablation and resurfacing of the skin for the reduction, removal and/or clearance of cellular-based benign lesions. The intended use of the CellFX System is for the reduction, removal and/or clearance of cellular-based benign lesions, including sebaceous hyperplasia, cutaneous non-genital warts and seborrheic keratosis.

Scientific publications

These peer-reviewed scientific publications are for medical education on the safety and efficacy profile of NPS technology.

Safety and Efficacy of Nano-Pulse Stimulation Treatment of Non-Genital, Cutaneous Warts (Verrucae)

Nuccitelli R, LaTowsky B, Lain E, et al. Lasers in Surgery and Medicine, 2021.

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A Dose-Response Study of Nanosecond Electric Energy Pulses on Facial Skin.

Newman J, Jauregui L, Knape WA, et al. Journal of Cosmetic and Laser Therapy, 2020.

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Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia.

Munavalli G, Zelickson B, Selim M, et al.  Dermatologic Surgery, 2020.

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Nano‐Pulse Stimulation Induces Changes in the Intracellular Organelles in Rat Liver Tumors Treated In Situ.

Nuccitelli R, McDaniel A, Connolly R, Zelickson B, Hartman H. Lasers in Surgery and Medicine, 2020.

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Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Seborrheic Keratoses.

Hruza G, Zelickson B, Selim M, et al.  Dermatologic Surgery, 2020.

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Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions.

Nuccitelli R.  Bioelectricity, 2019.

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A Dose-Response Study of a Novel Method of Selective Tissue Modification of Cellular Structures in the Skin With Nanosecond Pulsed Electric Fields.

Kaufman D, Martinez M, Jauregui L, et al. Lasers in Surgery and Medicine, 2019.

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Nano-Pulse Stimulation Induces Immunogenic Cell Death in Human Papillomavirus-Transformed Tumors and Initiates an Adaptive Immune Response.

Skeate JG, Da Silva DM, Chavez-Juan E, Anand S, Nuccitelli R, Kast WM. PLOS ONE, 2018.

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Nano-Pulse Stimulation Is a Physical Modality That Can Trigger Immunogenic Tumor Cell Death.

Nuccitelli R, McDaniel A, Anand S, et al. Journal for ImmunoTherapy of Cancer, 2017.

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First-in-Human Trial of Nanoelectroablation Therapy for Basal Cell Carcinoma: Proof of Method.

Nuccitelli R, Wood R, Kreis M, et al.  Experimental Dermatology, 2014.

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Non-Thermal Nanoelectroablation of UV-Induced Murine Melanomas Stimulates an Immune Response.

Nuccitelli R, Tran K, Lui K, et al.  Pigment Cell Melanoma Research, 2012.

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Scientific presentations and posters

The following list of podium and poster presentations was generated by key opinion leaders (KOLs) in dermatology and plastic surgery with whom Pulse Biosciences has collaborated to conduct clinical studies in the advancement of NPS technology for the scientific and medical community.

ASLMS

May 2021, ANNUAL MEETING
Katz B.

Multi-Center Study of Nano-Pulse Stimulation (NPS) Technology for the Treatment of Moderate-to-Severe Acne Vulgaris of the Back: A Feasibility Study (Interim Results).

ASLMS

May 2021, ANNUAL MEETING
Cohen J.

A Prospective, Non-Randomized, Multicenter Pivotal Study of Nano-Pulse Stimulation (NPS) for Treatment of Cutaneous Non-Genital Warts. 

ASLMS

May 2021, ANNUAL MEETING
Kilmer S.

A Feasibility Study for the Treatment of Moderate to Severe Acne Vulgaris of the Back Using Nano-Pulse Stimulation Energy. 

ASLMS

May 2021, ANNUAL MEETING
Lain T.

A Dose-Response Study of a Novel Non-Thermal Method of Selectively Modifying Cellular Structures in Skin with Low Energy Nanosecond Electrical Stimulation

ASDS

OCTOBER 2020, ANNUAL CONFERENCE
Munavalli G.

Histologic and Cinical Comparison of Scar Cosmesis Using Nano-Pulse Stimulation vs Traditional Surgical Treatments of Basal Cell Carcinoma.

ASDS

OCTOBER 2020, ANNUAL CONFERENCE
Geronemus R.

Lower Energy Settings with Nano-Pulse Stimulation (NPS) Procedure to Treat Sebaceous Hyperplasia Yield High Efficacy and Superior Skin Recovery (Interim Results).

ASDS

OCTOBER 2020, ANNUAL CONFERENCE
Harmon C, Nestor M, Munavalli G, et al.

A Feasibility Study of Non-Thermal Nano-Pulse Stimulation (NPS) Technology for Treating Common Nevi.

ASDS

OCTOBER 2020, ANNUAL CONFERENCE
Lain E.

Histology of Cellular Sebaceous Glands After Nano-Pulse Stimulation Procedure Demonstrates Mechanism for High Sebaceous Hyperplasia Clearance Rate in Clinical Use. 

MOA Symposium

AUGUST 2020, VIRTUAL CONFERENCE
Kilmer S.

Multi-Center Study of Nano-Pulse Stimulation (NPS) Technology for the Treatment of Moderate-to-Severe Acne Vulgaris of the Back: A Feasibility Study (Interim Results).

SCALE

JULY 2020, VIRTUAL CONFERENCE
Ross EV.

First Clinical Use of Non-Thermal Nano-Pulse Stimulation Treatment to Eliminate Seborrheic Keratosis Lesions. 

ASLMS

JULY 2020, VIRTUAL CONFERENCE
Ross EV.

A First Human Feasibility Study of Nano-Pulse Stimulation (NPS) to Evaluate the Potential Elimination of a Biopsy-Confirmed Nodular or Superficial BCC in a Short-Term Treat and Resect Study Design

ASLMS

JULY 2020, VIRTUAL CONFERENCE
Munavalli, G.

Nano-Pulse Stimulation (NPS) Technology. 

ASLMS

JULY 2020, VIRTUAL CONFERENCE
Rohrer T.

Nano-Pulse Stimulation Technology. 

IMCAS

JANUARY 2020, WORLD CONGRESS
Munavalli G, et al.

Aesthetic Trends: Nano-Pulse Stimulation Technology.

ODAC

JANUARY 2020, CONFERENCE
Ross EV.

A Dose-Ranging, Multi-Center Pivotal Study Using the Nano-Pulse Stimulation Procedure for Sebaceous Hyperplasia. 

Maui Derm

JANUARY 2020, ANNUAL MEETING
Kilmer S, et al.

Histologic and Cinical Comparison of Scar Cosmesis Using Nano-Pulse Stimulation vs Traditional Surgical Treatments of Basal Cell Carcinoma.

Winter Clin Derm

JANUARY 2020, CONFERENCE
Moy R.

Non-Thermal Nano-Pulse Stimulation (NPS) Technology for Treating Cutaneous, Non-Genital Warts: A Feasibility Study. 

ASDS

OCTOBER 2019, ANNUAL MEETING
Nestor M, et al.

Safety and Efficacy of Nano-Pulse Stimulation in the Treatment of Patients with Sebaceous Hyperplasia. 

ASDS

OCTOBER 2019, ANNUAL MEETING
Munavalli G, et al.

Nano-Pulse Stimulation Technology (What’s New in Dermatologic Surgery).

ASDS

OCTOBER 2019, ANNUAL MEETING
Ross EV, et al.

High Amplitude Electromagnetic Fields – A New Player in Dermatology.

Harvard

OCTOBER 2019, ANNUAL MEETING
Avram M.

Nano-Pulse Stimulation (NPS) Dose-Titration Study for the Treatment of Sebaceous Hyperplasia – A Multi-Center Pivotal Study. 

Controversies & Conversations

AUGUST 2019, ANNUAL SYMPOSIUM
Zelickson B.

A Multicenter, Pivotal Study Using the Nano-Pulse Stimulation Procedure to Treat Sebaceous Hyperplasia Lesions. 

Controversies & Conversations

AUGUST 2019, ANNUAL SYMPOSIUM
Munavalli G.

First Clinical Use of Non-Thermal Nano-Pulse Stimulation Technology for Treating Cutaneous, Non-Genital Warts.

Controversies & Conversations

AUGUST 2019, ANNUAL SYMPOSIUM
Rohrer T.

Nano-Pulse Stimulation (NPS) Procedure to Treat Sebaceous Hyperplasia: A Dose-Ranging, Multi-Center, Pivotal Study. 

AAD

MARCH 2019, ANNUAL MEETING
Munavalli G, et al.

Safety and Efficacy of NPS in the Treatment of Sebaceous Hyperplasia and Verrucae. 

ASLMS

MARCH 2019, ANNUAL MEETING
Ross EV, et al.

Hot Topics: Nano-Pulse Stimulation. 

ASLMS

MARCH 2019, ANNUAL MEETING
Kilmer S, et al.

Nano-Pulse Stimulation Technology. 

Maui Derm

JANUARY 2019, ANNUAL MEETING
Kilmer S, et al.

Nano-Pulse Stimulation (NPS) Technology for Treating Tattoos and Basal Cell Carcinomas – Initial Observations. 

ASDS

OCTOBER 2018, ANNUAL MEETING
Hruza G, et al.

First Clinical Use of Non-Thermal Nano-Pulse Stimulation Procedure to Eliminate Sebaceous Hyperplasia Lesions. 

ASLMS

APRIL 2018, ANNUAL MEETING
Kaufman D, et al.

High Amplitude, Nanosecond Electrical Pulsing for Warts. 

ASLMS

APRIL 2018, ANNUAL MEETING
Rohrer T, et al.

Non-Thermal Nano-Pulse Stimulation (NPS) Procedure for Treating Cutaneous, Non-Genital Warts Shows High Clearance Efficacy with a Single Session (Interim Results).